Research workbench

Structural basis for the sugar nucleotide and acyl chain selectivity of leptospira interrogans lpxa

Analyse Structural basis for the sugar nucleotide and acyl chain selectivity of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HSQ
Type: protein
Length: 777 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acyl-[acyl-carrier-protein]--udp-N- acetylglucosamine O-acyltransferase
EC: 2.3.1.129
UniProt: Q8EZA6
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Acyl-[acyl-carrier-protein]--udp-N- acetylglucosamine O-acyltransferase (EC 2.3.1.129)	protein	259	16% helix, 29% strand	Q8EZA6

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	724	0.77	0.82	56	empty
2	127	0.59	0.84	21	empty
3	60	0.37	0.79	13	empty
4	62	0.35	0.77	17	empty
5	52	0.30	0.76	13	empty

Interfaces

2 interfaces between chains.

A–B · 490 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 425 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3HSQ · Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8EZA6
Elsewhere: RCSB PDB 3HSQ · PDBe 3HSQ · UniProt Q8EZA6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.