Crystal structure of human collagen xviii trimerization domain (tetragonal crystal form)

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 44% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · 13 copies · chains A, B, C, D, F, E
• GOL · Glycerol · additive · 9 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

10 interfaces between chains.

• E–F · 1059 Ų buried · 10 hydrogen bonds · protein-protein
• D–F · 1057 Ų buried · 10 hydrogen bonds · protein-protein
• A–C · 1047 Ų buried · 15 hydrogen bonds · protein-protein
• A–B · 1043 Ų buried · 11 hydrogen bonds · protein-protein
• B–C · 1034 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

• 3HSH · Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form) · the same entry in another collection · chain F against F, TM-score 1.00
• P39060 · AlphaFold monomer V2.0 prediction for collagen alpha-1(XVIII) chain (P39060) · a predicted model of the same protein · chain E against A, TM-score 0.84

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P39060
• Elsewhere: RCSB PDB 3HSH · PDBe 3HSH · UniProt P39060