Research workbench
Crystal structure of the frizzled-like cysteine-rich domain of musk
Analyse Crystal structure of the frizzled-like cysteine-rich domain of musk in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HKL
- Type
- protein
- Length
- 294 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Muscle, skeletal receptor tyrosine protein kinase
- EC
- 2.7.10.1
- UniProt
- Q62838
- Ligands
- NAG
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) | protein | 141 | 40% helix, 9% strand | Q62838 |
| B | Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) | protein | 153 | 29% helix, 10% strand | Q62838 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.43 | 0.76 | 17 | empty |
| 2 | 51 | 0.41 | 0.82 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 832 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 3HKL · Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK · the same entry in another collection · chain A against A, TM-score 1.00
- Q62838 · AlphaFold monomer V2.0 prediction for muscle, skeletal receptor tyrosine protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62838
- Elsewhere: RCSB PDB 3HKL · PDBe 3HKL · UniProt Q62838
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