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Crystal structure of the carboxy-terminal domain of HSP90 from leishmania major, LMJF33.0312

Analyse Crystal structure of the carboxy-terminal domain of HSP90 from leishmania… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HJC
Type: protein
Length: 387 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock protein 83-1
UniProt: Q4Q4I6
Ligands: SO4
Pockets: 7 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein 83-1	protein	387	48% helix, 17% strand	Q4Q4I6

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.53	0.84	24	empty
2	173	0.51	0.78	23	empty
3	74	0.41	0.79	18	empty
4	116	0.41	0.76	16	empty
5	95	0.37	0.75	19	empty

Compared structures

3HJC · Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4Q4I6
Elsewhere: RCSB PDB 3HJC · PDBe 3HJC · UniProt Q4Q4I6

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