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Minor editosome-associated tutase 1 with bound UTP

Analyse Minor editosome-associated tutase 1 with bound UTP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HJ1
Type: protein
Length: 771 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Minor editosome-associated tutase
UniProt: Q4GZ86
Ligands: UTP
Pockets: 10 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Minor editosome-associated tutase	protein	384	58% helix, 9% strand	Q4GZ86
B	Minor editosome-associated tutase	protein	387	56% helix, 9% strand	Q4GZ86

Ligands and binding sites

UTP · Uridine 5'-triphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	932	0.76	0.79	63	UTP
2	823	0.76	0.80	76	UTP
3	338	0.63	0.79	44	empty
4	64	0.43	0.82	19	empty
5	109	0.41	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 821 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3HJ1 · Minor Editosome-Associated TUTase 1 with bound UTP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4GZ86
Elsewhere: RCSB PDB 3HJ1 · PDBe 3HJ1 · UniProt Q4GZ86

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