Research workbench
Crystal structure of Fab fragment of al-57
Analyse Crystal structure of Fab fragment of al-57 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HI5
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain of Fab fragment of al-57 against alpha L I domain; Light chain of Fab…
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Heavy chain of Fab fragment of al-57 against alpha L I domain | protein | 219 | 4% helix, 50% strand | — |
| L | Light chain of Fab fragment of al-57 against alpha L I domain | protein | 211 | 7% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.54 | 0.75 | 34 | empty |
| 2 | 134 | 0.46 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- H–L · 1807 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3HI5 · Crystal structure of Fab fragment of AL-57 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3HI5 · PDBe 3HI5
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