Research workbench
Structure of crga regulatory domain, a lysr-type transcriptional regulator from neisseria meningitidis.
Analyse Structure of crga regulatory domain, a lysr-type transcriptional regulator from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HHF
- Type
- protein
- Length
- 406 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator, lysr family
- UniProt
- Q9JXW7
- Ligands
- CL
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Transcriptional regulator, lysr family | protein | 202 | 38% helix, 30% strand | Q9JXW7 |
| A | Transcriptional regulator, lysr family | protein | 204 | 36% helix, 30% strand | Q9JXW7 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 957 | 0.76 | 0.78 | 91 | CL |
| 2 | 302 | 0.53 | 0.75 | 33 | empty |
Interfaces
1 interface between chains.
- B–A · 1359 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3HHF · Structure of CrgA regulatory domain, a LysR-type transcriptional regulator from Neisseria… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JXW7
- Elsewhere: RCSB PDB 3HHF · PDBe 3HHF · UniProt Q9JXW7
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