Research workbench
Crystal structure of human tryptophan hydroxylase type 1 with bound lp-521834 and fe
Analyse Crystal structure of human tryptophan hydroxylase type 1 with bound lp-521834… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HF6
- Type
- protein
- Length
- 280 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan 5-hydroxylase 1
- EC
- 1.14.16.4
- UniProt
- P17752
- Ligands
- LX0, FE
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) | protein | 280 | 52% helix, 10% strand | P17752 |
Ligands and binding sites
- LX0 · 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine · ligand · chains A
- FE · Fe (III) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 424 | 0.75 | 0.84 | 38 | FE, LX0 |
| 2 | 66 | 0.53 | 0.87 | 15 | empty |
| 3 | 86 | 0.39 | 0.77 | 17 | empty |
Compared structures
- 3HF6 · Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE · the same entry in another collection · chain A against A, TM-score 1.00
- P17752 · AlphaFold monomer V2.0 prediction for tryptophan 5-hydroxylase 1 (P17752) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17752
- Elsewhere: RCSB PDB 3HF6 · PDBe 3HF6 · UniProt P17752
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