Exploring backbone pattern in ALPHA/BETA-peptide helix bundles: the GCN4-pli side chain sequence on different (alpha-alpha-alpha-beta) backbones

Structure

x-ray diffraction · 1 distinct chain · 85% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · 3 copies · chains A, B, C
• TAM · Tris(hydroxyethyl)aminomethane · ligand · chains A, B
• TBU · Tertiary-butyl alcohol · additive · 3 copies · chains A, C, B
• GOL · Glycerol · additive · 2 copies · chains A, C, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

• B–C · 789 Ų buried · 7 hydrogen bonds · protein-protein
• A–C · 789 Ų buried · 7 hydrogen bonds · protein-protein
• A–B · 638 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 24 modified, 3 covalent (nonstandard, covalent ligand).

Compared structures

• 3HEZ · Exploring backbone pattern in alpha/beta-peptide helix bundles: The GCN4-pLI side chain… · the same entry in another collection · chain B against B, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Elsewhere: RCSB PDB 3HEZ · PDBe 3HEZ