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Heterospecific coiled-coil pair SYNZIP2:SYNZIP1

Analyse Heterospecific coiled-coil pair SYNZIP2:SYNZIP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HE5
Type: protein
Length: 282 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SYNZIP1; SYNZIP2
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 4 distinct chains · 95% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E	SYNZIP1	protein	47	96% helix, 0% strand	—
B	SYNZIP2	protein	48	92% helix, 0% strand	—
C	SYNZIP1	protein	46	96% helix, 0% strand	—
D, F	SYNZIP2	protein	47	96% helix, 0% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	661	0.68	0.77	54	empty
2	61	0.31	0.76	11	empty
3	74	0.29	0.73	14	empty

Interfaces

9 interfaces between chains.

C–D · 1300 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 1264 Å² buried · 5 hydrogen bonds · protein-protein
E–F · 1230 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 144 Å² buried · 1 hydrogen bond · protein-protein
B–F · 120 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3HE5 · Heterospecific coiled-coil pair SYNZIP2:SYNZIP1 · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3HE5 · PDBe 3HE5

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