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The crystal structure of the domain of putative two-component sensor histidine kinase protein from sinorhizobium meliloti 1021

Analyse The crystal structure of the domain of putative two-component sensor histidine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HCY
Type: protein
Length: 289 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative two-component sensor histidine kinase protein
UniProt: Q92UP1
Pockets: 6 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative two-component sensor histidine kinase protein	protein	145	42% helix, 24% strand	Q92UP1
B	Putative two-component sensor histidine kinase protein	protein	144	38% helix, 25% strand	Q92UP1

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.57	0.86	19	empty
2	108	0.57	0.84	25	empty
3	87	0.41	0.78	17	empty
4	103	0.38	0.75	18	empty
5	72	0.32	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 1059 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

3HCY · The crystal structure of the domain of putative two-component sensor histidine kinase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92UP1
Elsewhere: RCSB PDB 3HCY · PDBe 3HCY · UniProt Q92UP1

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