Research workbench
BHA10 IGG1 Fab quadruple mutant variant - antibody directed at human ltbr
Analyse BHA10 IGG1 Fab quadruple mutant variant - antibody directed at human ltbr in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HC4
- Type
- protein
- Length
- 425 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin IGG1 Fab, heavy chain; Immunoglobulin IGG1 Fab, light chain
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Immunoglobulin IGG1 Fab, heavy chain | protein | 212 | 9% helix, 54% strand | — |
| L | Immunoglobulin IGG1 Fab, light chain | protein | 213 | 6% helix, 51% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.48 | 0.83 | 22 | empty |
| 2 | 159 | 0.44 | 0.75 | 34 | empty |
| 3 | 208 | 0.43 | 0.72 | 29 | empty |
| 4 | 75 | 0.36 | 0.76 | 15 | empty |
| 5 | 79 | 0.36 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- H–L · 1602 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3HC4 · BHA10 IgG1 Fab quadruple mutant variant - antibody directed at human LTBR · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3HC4 · PDBe 3HC4
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