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Crystal structure of human fibroblast growth factor homologous factor 2A (FHF2A), also referred to as fibroblast growth factor 13A (FGF13A)

Analyse Crystal structure of human fibroblast growth factor homologous factor 2A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HBW
Type: protein
Length: 298 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor 13
UniProt: Q92913
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fibroblast growth factor 13	protein	149	8% helix, 50% strand	Q92913

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	391	0.75	0.85	41	empty
2	92	0.35	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 633 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

3HBW · Crystal Structure of Human Fibroblast Growth Factor Homologous Factor 2A (FHF2A), also… · the same entry in another collection · chain A against A, TM-score 1.00
Q92913 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 13 (Q92913) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92913
Elsewhere: RCSB PDB 3HBW · PDBe 3HBW · UniProt Q92913

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