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Crystal structure of the complex of human chromobox homolog 2 (CBX2) and H3K27 peptide
Analyse Crystal structure of the complex of human chromobox homolog 2 (CBX2) and H3K27… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3H91
- Type
- protein
- Length
- 122 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromobox protein homolog 2; H3K27 peptide
- UniProt
- Q14781
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chromobox protein homolog 2 | protein | 52 | 27% helix, 50% strand | Q14781 |
| C, D | H3K27 peptide | protein | 9 | 0% helix, 33% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 301 | 0.53 | 0.74 | 33 | empty |
Interfaces
3 interfaces between chains.
- A–C · 769 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 768 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 358 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (methylation).
Compared structures
- 3H91 · Crystal structure of the complex of human chromobox homolog 2 (CBX2) and H3K27 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q14781 · AlphaFold monomer V2.0 prediction for chromobox protein homolog 2 (Q14781) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14781
- Elsewhere: RCSB PDB 3H91 · PDBe 3H91 · UniProt Q14781
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