Research workbench

Low pH native structure of leucine aminopeptidase from pseudomonas putida

Analyse Low pH native structure of leucine aminopeptidase from pseudomonas putida in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3H8E
Type: protein
Length: 946 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytosol aminopeptidase
EC: 3.4.11.1
UniProt: O86436
Pockets: 9 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cytosol aminopeptidase (EC 3.4.11.1)	protein	473	39% helix, 21% strand	O86436

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	448	0.64	0.78	39	empty
2	437	0.64	0.78	40	empty
3	159	0.45	0.75	24	empty
4	81	0.44	0.80	19	empty
5	86	0.43	0.80	21	empty

Interfaces

1 interface between chains.

A–B · 1167 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3H8E · Low pH native structure of leucine aminopeptidase from Pseudomonas putida · the same entry in another collection · chain A against A, TM-score 1.00
O86436 · AlphaFold monomer V2.0 prediction for cytosol aminopeptidase (O86436) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O86436
Elsewhere: RCSB PDB 3H8E · PDBe 3H8E · UniProt O86436

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.