Research workbench
Crystal structure of pqsd, a key enzyme in pseudomonas aeruginosa quinolone signal biosynthesis pathway
Analyse Crystal structure of pqsd, a key enzyme in pseudomonas aeruginosa quinolone… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3H76
- Type
- protein
- Length
- 658 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pqs biosynthetic enzyme
- EC
- 2.3.1.180
- UniProt
- P20582
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pqs biosynthetic enzyme (EC 2.3.1.180) | protein | 329 | 40% helix, 25% strand | P20582 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.76 | 0.91 | 49 | empty |
| 2 | 169 | 0.71 | 0.89 | 38 | empty |
| 3 | 233 | 0.51 | 0.76 | 39 | empty |
| 4 | 78 | 0.35 | 0.76 | 16 | empty |
| 5 | 74 | 0.35 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2836 Ų buried · 56 hydrogen bonds · protein-protein
Compared structures
- 3H76 · Crystal structure of PqsD, a key enzyme in Pseudomonas aeruginosa quinolone signal… · the same entry in another collection · chain A against A, TM-score 1.00
- P20582 · AlphaFold monomer V2.0 prediction for anthraniloyl-CoA anthraniloyltransferase (P20582) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20582
- Elsewhere: RCSB PDB 3H76 · PDBe 3H76 · UniProt P20582
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