Research workbench
Crystal structure of the bovine beta 1,4 galactosyltransferase (B4GALT1) catalytic domain complexed with ump
Analyse Crystal structure of the bovine beta 1,4 galactosyltransferase (B4GALT1)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FGX
- Type
- protein
- Length
- 545 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta 1,4 galactosyltransferase
- EC
- 2.4.1.38
- UniProt
- P08037
- Ligands
- U5P
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta 1,4 galactosyltransferase (EC 2.4.1.38) | protein | 272 | 24% helix, 22% strand | P08037 |
| B | Beta 1,4 galactosyltransferase (EC 2.4.1.38) | protein | 273 | 26% helix, 21% strand | P08037 |
Ligands and binding sites
- U5P · Uridine-5'-monophosphate · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1157 | 0.78 | 0.80 | 75 | U5P |
| 2 | 299 | 0.54 | 0.75 | 34 | empty |
| 3 | 117 | 0.40 | 0.75 | 17 | empty |
| 4 | 58 | 0.37 | 0.79 | 18 | empty |
| 5 | 68 | 0.33 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 783 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1FGX · Crystal structure of the bovine beta 1,4 galactosyltransferase (B4GALT1) catalytic domain… · the same entry in another collection · chain A against A, TM-score 1.00
- P08037 · AlphaFold monomer V2.0 prediction for beta-1,4-galactosyltransferase 1 (P08037) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08037
- Elsewhere: RCSB PDB 1FGX · PDBe 1FGX · UniProt P08037
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