Research workbench
LEUD_1-156 small subunit of isopropylmalate isomerase (RV2987C) from mycobacterium tuberculosis
Analyse LEUD_1-156 small subunit of isopropylmalate isomerase (RV2987C) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3H5E
- Type
- protein
- Length
- 306 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-isopropylmalate dehydratase small subunit
- EC
- 4.2.1.33
- UniProt
- P65277
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) | protein | 154 | 34% helix, 25% strand | P65277 |
| B | 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) | protein | 152 | 35% helix, 26% strand | P65277 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.37 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 115 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3H5E · LeuD_1-156 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P65277
- Elsewhere: RCSB PDB 3H5E · PDBe 3H5E · UniProt P65277
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