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Crystal structure of pombe ampk kdaid fragment

Analyse Crystal structure of pombe ampk kdaid fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3H4J
Type: protein
Length: 646 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SNF1-like protein kinase SSP2
EC: 2.7.11.1
UniProt: O74536
Pockets: 10 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	SNF1-like protein kinase SSP2 (EC 2.7.11.1)	protein	330	37% helix, 16% strand	O74536
A	SNF1-like protein kinase SSP2 (EC 2.7.11.1)	protein	316	40% helix, 16% strand	O74536

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1026	0.77	0.79	109	empty
2	535	0.73	0.81	79	empty
3	142	0.57	0.83	26	empty
4	146	0.47	0.77	18	empty
5	132	0.42	0.76	30	empty

Interfaces

1 interface between chains.

B–A · 2899 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

3H4J · crystal structure of pombe AMPK KDAID fragment · the same entry in another collection · chain B against B, TM-score 1.00
O74536 · AlphaFold monomer V2.0 prediction for SNF1-like protein kinase SSP2 (O74536) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O74536
Elsewhere: RCSB PDB 3H4J · PDBe 3H4J · UniProt O74536

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