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Crystal structure of the catalytic domain of primase repb' in complex with initiator DNA

Analyse Crystal structure of the catalytic domain of primase repb' in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3H25
Type: protein + DNA
Length: 215 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replication protein B; Single stranded initiator DNA (ssia)
UniProt: Q52349
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replication protein B	protein	188	38% helix, 27% strand	Q52349
C	Single stranded initiator DNA (ssia)	dna	27	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.31	0.73	19	empty

Interfaces

1 interface between chains.

A–C · 918 Å² buried · 19 hydrogen bonds · protein-nucleic

Compared structures

3H25 · Crystal structure of the catalytic domain of primase Repb' in complex with initiator DNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q52349
Elsewhere: RCSB PDB 3H25 · PDBe 3H25 · UniProt Q52349

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