Research workbench

Structure of adenylosuccinate synthetase at pH 6.5 and 25 degrees celsius

Analyse Structure of adenylosuccinate synthetase at pH 6.5 and 25 degrees celsius in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ADI
Type: protein
Length: 862 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylosuccinate synthetase
EC: 6.3.4.4
UniProt: P0A7D4
Pockets: 10 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Adenylosuccinate synthetase (EC 6.3.4.4)	protein	431	35% helix, 20% strand	P0A7D4

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.84	0.96	35	empty
2	1140	0.80	0.82	105	empty
3	1025	0.78	0.80	80	empty
4	132	0.77	0.95	31	empty
5	111	0.73	0.94	23	empty

Interfaces

1 interface between chains.

A–B · 2926 Å² buried · 51 hydrogen bonds · protein-protein

Compared structures

1ADI · Structure of adenylosuccinate synthetase at pH 6.5 and 25 degrees celsius · the same entry in another collection · chain A against A, TM-score 1.00
P0A7D4 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase (P0A7D4) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A7D4
Elsewhere: RCSB PDB 1ADI · PDBe 1ADI · UniProt P0A7D4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.