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Y97L/G100-/E101- mutant in organophosphorus hydrolase

Analyse Y97L/G100-/E101- mutant in organophosphorus hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3GU2
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Organophosphorus hydrolase
UniProt: Q9RVU2
Ligands: CO
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Organophosphorus hydrolase	protein	330	44% helix, 15% strand	Q9RVU2

Ligands and binding sites

CO · Cobalt (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	174	0.60	0.83	28	CO
2	50	0.44	0.85	14	empty
3	56	0.25	0.72	15	empty

Modifications

Observed in the structure: 1 modified (carboxylation).

Compared structures

3GU2 · Y97L/G100-/E101- mutant in organophosphorus hydrolase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9RVU2
Elsewhere: RCSB PDB 3GU2 · PDBe 3GU2 · UniProt Q9RVU2

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