Research workbench
Crystal structure of a sensor protein from polaromonas sp. JS666
Analyse Crystal structure of a sensor protein from polaromonas sp. JS666 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GRC
- Type
- protein
- Length
- 498 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein, kinase
- EC
- 2.7.13.3
- UniProt
- Q121U0
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Sensor protein, kinase (EC 2.7.13.3) | protein | 125 | 46% helix, 18% strand | Q121U0 |
| B | Sensor protein, kinase (EC 2.7.13.3) | protein | 123 | 38% helix, 18% strand | Q121U0 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1004 | 0.76 | 0.78 | 98 | empty |
| 2 | 139 | 0.58 | 0.84 | 23 | empty |
Interfaces
5 interfaces between chains.
- A–B · 605 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 509 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 283 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 238 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 219 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 modified (engineered).
Compared structures
- 3GRC · Crystal structure of a sensor protein from Polaromonas sp. JS666 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q121U0
- Elsewhere: RCSB PDB 3GRC · PDBe 3GRC · UniProt Q121U0
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