Research workbench
Crystal structure of tip-1 in complex with C-terminal of KIR2.3
Analyse Crystal structure of tip-1 in complex with C-terminal of KIR2.3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GJ9
- Type
- protein
- Length
- 226 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TAX1-binding protein 3; C-terminal peptide from inward rectifier potassium channel 4
- UniProt
- O14907, P48050
- Ligands
- ZN, CL
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TAX1-binding protein 3 | protein | 108 | 15% helix, 39% strand | O14907 |
| B | TAX1-binding protein 3 | protein | 106 | 12% helix, 38% strand | O14907 |
| C, D | C-terminal peptide from inward rectifier potassium channel 4 | protein | 6 | 0% helix, 33% strand | P48050 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.48 | 0.75 | 40 | empty |
| 2 | 51 | 0.39 | 0.82 | 15 | CL |
| 3 | 68 | 0.37 | 0.78 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–D · 591 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 575 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 463 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3GJ9 · crystal structure of TIP-1 in complex with c-terminal of Kir2.3 · the same entry in another collection · chain A against A, TM-score 1.00
- O14907 · AlphaFold monomer V2.0 prediction for TAX1-binding protein 3 (O14907) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P48050 · AlphaFold monomer V2.0 prediction for inward rectifier potassium channel 4 (P48050) · a predicted model of the same protein · chain C against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14907
- Every structure of UniProt P48050
- Elsewhere: RCSB PDB 3GJ9 · PDBe 3GJ9 · UniProt O14907 · UniProt P48050
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