Research workbench
Crystal structure of apct K158A transporter bound to 7F11 monoclonal Fab fragment
Analyse Crystal structure of apct K158A transporter bound to 7F11 monoclonal Fab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GI8
- Type
- protein
- Length
- 875 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein MJ0609; 7F11 anti-apct monoclonal Fab light chain; 7F11 anti-apct…
- UniProt
- Q58026
- Pockets
- 13 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Uncharacterized protein MJ0609 | protein | 435 | 77% helix, 0% strand | Q58026 |
| L | 7F11 anti-apct monoclonal Fab light chain | protein | 220 | 5% helix, 51% strand | — |
| H | 7F11 anti-apct monoclonal Fab heavy chain | protein | 220 | 7% helix, 54% strand | — |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 471 | 0.60 | 0.75 | 47 | empty |
| 2 | 145 | 0.58 | 0.83 | 28 | empty |
| 3 | 165 | 0.57 | 0.82 | 24 | empty |
| 4 | 106 | 0.39 | 0.76 | 21 | empty |
| 5 | 106 | 0.38 | 0.76 | 24 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1962 Ų buried · 14 hydrogen bonds · protein-protein
- C–H · 823 Ų buried · 9 hydrogen bonds · protein-protein
- C–L · 115 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 3GI8 · Crystal Structure of ApcT K158A Transporter Bound to 7F11 Monoclonal Fab Fragment · the same entry in another collection · chain C against C, TM-score 1.00
- Q58026 · AlphaFold monomer V2.0 prediction for uncharacterized protein MJ0609 (Q58026) · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58026
- Elsewhere: RCSB PDB 3GI8 · PDBe 3GI8 · UniProt Q58026
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.