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Female-specific histamine-binding protein, D24R mutant

Analyse Female-specific histamine-binding protein, D24R mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3GAQ
Type: protein
Length: 344 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Female-specific histamine-binding protein 2
UniProt: O77421
Pockets: 3 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Female-specific histamine-binding protein 2	protein	172	18% helix, 42% strand	O77421

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.45	0.84	17	empty
2	50	0.41	0.83	16	empty
3	144	0.41	0.75	26	empty

Interfaces

1 interface between chains.

A–B · 424 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3GAQ · Female-specific Histamine-Binding Protein, D24R Mutant · the same entry in another collection · chain A against A, TM-score 1.00
O77421 · AlphaFold monomer V2.0 prediction for female-specific histamine- binding protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O77421
Elsewhere: RCSB PDB 3GAQ · PDBe 3GAQ · UniProt O77421

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