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Crystal structure of ndp-N-acetyl-D-galactosaminuronic acid dehydrogenase from methanosarcina mazei GO1

Analyse Crystal structure of ndp-N-acetyl-D-galactosaminuronic acid dehydrogenase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3G79
Type: protein
Length: 950 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ndp-N-acetyl-D-galactosaminuronic acid dehydrogenase
EC: 1.1.1.-
UniProt: Q8PXR2
Pockets: 11 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ndp-N-acetyl-D-galactosaminuronic acid dehydrogenase (EC 1.1.1.-)	protein	475	42% helix, 13% strand	Q8PXR2

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	936	0.76	0.78	84	empty
2	1189	0.75	0.78	85	empty
3	50	0.72	0.99	18	empty
4	179	0.50	0.77	19	empty
5	123	0.40	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 2867 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

3G79 · Crystal structure of NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8PXR2
Elsewhere: RCSB PDB 3G79 · PDBe 3G79 · UniProt Q8PXR2

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