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Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Analyse Antibodies specifically targeting a locally misfolded region of tumor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3G5Z
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 175 light chain; 175 heavy chain
Pockets: 6 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	175 light chain	protein	213	3% helix, 50% strand	—
B	175 heavy chain	protein	217	3% helix, 49% strand	—

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	581	0.63	0.75	51	empty
2	110	0.39	0.75	23	empty
3	84	0.38	0.77	18	empty
4	87	0.31	0.73	22	empty
5	54	0.29	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 2008 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3G5Z · Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3G5Z · PDBe 3G5Z

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