Research workbench
Crystal structure of the glycopeptide N-methyltransferase mtfa complexed with (S)-adenosyl-L-methionine (SAM)
Analyse Crystal structure of the glycopeptide N-methyltransferase mtfa complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3G2O
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PCZA361.24
- UniProt
- O52805
- Ligands
- SAM
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PCZA361.24 | protein | 244 | 30% helix, 34% strand | O52805 |
| B | PCZA361.24 | protein | 228 | 27% helix, 35% strand | O52805 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 763 | 0.72 | 0.78 | 104 | SAM |
| 2 | 204 | 0.56 | 0.80 | 28 | empty |
| 3 | 93 | 0.37 | 0.76 | 15 | empty |
| 4 | 69 | 0.37 | 0.77 | 21 | empty |
| 5 | 76 | 0.36 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1623 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 3G2O · Crystal Structure of the Glycopeptide N-methyltransferase MtfA complexed with… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O52805
- Elsewhere: RCSB PDB 3G2O · PDBe 3G2O · UniProt O52805
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.