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Structure of grc

Analyse Structure of grc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FZZ
Type: protein
Length: 454 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Granzyme C
EC: 3.4.21.-
UniProt: P08882
Ligands: SO4
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Granzyme C (EC 3.4.21.-)	protein	227	8% helix, 38% strand	P08882

Ligands and binding sites

SO4 · Sulfate ion · ion · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	786	0.73	0.78	70	empty
2	66	0.40	0.80	20	empty
3	52	0.34	0.79	17	empty

Interfaces

1 interface between chains.

A–B · 581 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3FZZ · Structure of GrC · the same entry in another collection · chain A against A, TM-score 1.00
P08882 · AlphaFold monomer V2.0 prediction for granzyme C (P08882) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08882
Elsewhere: RCSB PDB 3FZZ · PDBe 3FZZ · UniProt P08882

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