Research workbench
Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG
Analyse Crystal structure of the C2 fragment of streptococcal protein G in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FCC
- Type
- protein
- Length
- 524 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1 MO61 Fc; Streptococcal protein G (C2 fragment)
- UniProt
- P01857, P19909
- Pockets
- 5 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | IGG1 MO61 Fc | protein | 206 | 11% helix, 41% strand | P01857 |
| C, D | Streptococcal protein G (C2 fragment) | protein | 56 | 23% helix, 39% strand | P19909 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.44 | 0.79 | 20 | empty |
| 2 | 79 | 0.39 | 0.78 | 17 | empty |
| 3 | 128 | 0.37 | 0.73 | 24 | empty |
| 4 | 78 | 0.33 | 0.75 | 19 | empty |
| 5 | 78 | 0.31 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1190 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 723 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 716 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1FCC · Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc… · the same entry in another collection · chain A against A, TM-score 1.00
- P19909 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein G (P19909) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01857
- Every structure of UniProt P19909
- Elsewhere: RCSB PDB 1FCC · PDBe 1FCC · UniProt P01857 · UniProt P19909
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