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Crystal structure of homo sapiens CLIC3
Analyse Crystal structure of homo sapiens CLIC3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FY7
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 3
- UniProt
- O95833
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 3 | protein | 219 | 51% helix, 11% strand | O95833 |
| B | Chloride intracellular channel protein 3 | protein | 219 | 50% helix, 11% strand | O95833 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 609 | 0.71 | 0.79 | 51 | SO4 |
| 2 | 502 | 0.69 | 0.80 | 48 | SO4 |
| 3 | 174 | 0.44 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1096 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95833
- Elsewhere: RCSB PDB 3FY7 · PDBe 3FY7 · UniProt O95833
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