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Acidic mammalian chinase, catalytic domain

Analyse Acidic mammalian chinase, catalytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FXY
Type: protein
Length: 1,510 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acidic mammalian chitinase
EC: 3.2.1.14
UniProt: Q9BZP6
Pockets: 13 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D	Acidic mammalian chitinase (EC 3.2.1.14)	protein	379	38% helix, 22% strand	Q9BZP6
B	Acidic mammalian chitinase (EC 3.2.1.14)	protein	373	39% helix, 23% strand	Q9BZP6

Pockets

13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.63	0.80	35	empty
2	690	0.63	0.73	55	empty
3	343	0.60	0.77	52	empty
4	358	0.59	0.76	42	empty
5	346	0.59	0.76	44	empty

Interfaces

4 interfaces between chains.

A–B · 784 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 562 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 287 Å² buried · 1 hydrogen bond · protein-protein
A–D · 147 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

3FXY · Acidic Mammalian Chinase, Catalytic Domain · the same entry in another collection · chain D against D, TM-score 1.00
Q9BZP6 · AlphaFold monomer V2.0 prediction for acidic mammalian chitinase (Q9BZP6) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BZP6
Elsewhere: RCSB PDB 3FXY · PDBe 3FXY · UniProt Q9BZP6

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