Research workbench
Crystal structure of the lysr-type transcriptional regulator tsar
Analyse Crystal structure of the lysr-type transcriptional regulator tsar in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FXQ
- Type
- protein
- Length
- 592 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysr type regulator of tsambcd
- UniProt
- P94678
- Ligands
- CL
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lysr type regulator of tsambcd | protein | 296 | 46% helix, 21% strand | P94678 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains A, B
- BME · Beta-mercaptoethanol · additive · 4 copies · chains A, B
- FMT · Formic acid · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.66 | 0.87 | 31 | FMT, CL |
| 2 | 221 | 0.65 | 0.83 | 48 | CL |
| 3 | 97 | 0.64 | 0.89 | 26 | empty |
| 4 | 116 | 0.48 | 0.79 | 22 | empty |
| 5 | 94 | 0.34 | 0.73 | 20 | GOL |
Interfaces
1 interface between chains.
- A–B · 1502 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 covalent (additive adduct).
Compared structures
- 3FXQ · Crystal structure of the LysR-type transcriptional regulator TsaR · the same entry in another collection · chain A against A, TM-score 1.00
- P94678 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator tsar (P94678) · a predicted model of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P94678
- Elsewhere: RCSB PDB 3FXQ · PDBe 3FXQ · UniProt P94678
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.