Research workbench
Crystal structure of human protein phosphatase 1A (PPM1A) bound with citrate at 10 mm of MN2+
Analyse Crystal structure of human protein phosphatase 1A (PPM1A) bound with citrate at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FXM
- Type
- protein
- Length
- 363 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein phosphatase 1A
- EC
- 3.1.3.16
- UniProt
- P35813
- Ligands
- MN, PO4
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein phosphatase 1A (EC 3.1.3.16) | protein | 363 | 37% helix, 29% strand | P35813 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · chains A
- FLC · Citrate anion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.44 | 0.78 | 20 | empty |
| 2 | 110 | 0.38 | 0.75 | 19 | MN, FLC |
| 3 | 64 | 0.34 | 0.77 | 18 | empty |
| 4 | 53 | 0.34 | 0.78 | 13 | empty |
Compared structures
- 3FXM · Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 10 mM of… · the same entry in another collection · chain A against A, TM-score 1.00
- P35813 · AlphaFold monomer V2.0 prediction for protein phosphatase 1A (P35813) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35813
- Elsewhere: RCSB PDB 3FXM · PDBe 3FXM · UniProt P35813
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