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Crystal structure of the Q8DWD8_STRMU protein from streptococcus mutans. northeast structural genomics consortium target SMR99.

Analyse Crystal structure of the Q8DWD8_STRMU protein from streptococcus mutans.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FVW
Type: protein
Length: 361 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative NAD(P)H-dependent FMN reductase
UniProt: Q8DWD8
Pockets: 2 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative NAD(P)H-dependent FMN reductase	protein	179	38% helix, 16% strand	Q8DWD8
B	Putative NAD(P)H-dependent FMN reductase	protein	182	43% helix, 16% strand	Q8DWD8

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.82	0.96	24	empty
2	230	0.70	0.86	36	empty

Interfaces

1 interface between chains.

A–B · 908 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

3FVW · Crystal structure of the Q8DWD8_STRMU protein from Streptococcus mutans. Northeast… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8DWD8
Elsewhere: RCSB PDB 3FVW · PDBe 3FVW · UniProt Q8DWD8

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