Crystal structure of the human glutamate receptor, GLUR5, ligand- binding core in complex with 8-epi-neodysiherbaine a in space group P1

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).

Ligands and binding sites

• 8EP · (2R,3aR,6R,7S,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-6,7-dihydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid · ligand · 2 copies · chains A, B
• SO4 · Sulfate ion · ion · 4 copies · chains A, B
• GOL · Glycerol · additive · 10 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 846 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 3FVO · Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex… · the same entry in another collection · chain A against A, TM-score 1.00
• P39086 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P39086) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P39086
• Elsewhere: RCSB PDB 3FVO · PDBe 3FVO · UniProt P39086