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Heat shock transcription factor DNA binding domain containing the P237A mutation

Analyse Heat shock transcription factor DNA binding domain containing the P237A mutation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FBS
Type: protein
Length: 177 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock factor protein
UniProt: P22121
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock factor protein	protein	87	40% helix, 17% strand	P22121
B	Heat shock factor protein	protein	90	39% helix, 18% strand	P22121

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.41	0.78	14	empty

Interfaces

1 interface between chains.

A–B · 365 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1FBS · Heat shock transcription factor DNA binding domain containing the P237A mutation · the same entry in another collection · chain A against A, TM-score 1.00
P22121 · AlphaFold monomer V2.0 prediction for heat shock transcription factor (P22121) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22121
Elsewhere: RCSB PDB 1FBS · PDBe 1FBS · UniProt P22121

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