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Crystal structure of the calx-beta domain of integrin BETA4, calcium soak

Analyse Crystal structure of the calx-beta domain of integrin BETA4, calcium soak in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FSO
Type: protein
Length: 221 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin beta-4
UniProt: P16144
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 1% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin beta-4	protein	109	3% helix, 59% strand	P16144
B	Integrin beta-4	protein	112	0% helix, 56% strand	P16144

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.46	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 551 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

3FSO · Crystal structure of the Calx-beta domain of integrin beta4, calcium soak · the same entry in another collection · chain A against A, TM-score 1.00
P16144 · AlphaFold monomer V2.0 prediction for integrin beta-4 (P16144) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16144
Elsewhere: RCSB PDB 3FSO · PDBe 3FSO · UniProt P16144

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