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The pwwp domain of human DNA (cytosine-5-)-methyltransferase 3 beta

Analyse The pwwp domain of human DNA (cytosine-5-)-methyltransferase 3 beta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FLG
Type: protein
Length: 135 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (cytosine-5)-methyltransferase 3B
EC: 2.1.1.37
UniProt: Q9UBC3
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37)	protein	135	36% helix, 17% strand	Q9UBC3

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.31	0.76	14	empty

Compared structures

3FLG · The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta · the same entry in another collection · chain A against A, TM-score 1.00
Q9UBC3 · AlphaFold monomer V2.0 prediction for DNA (cytosine-5)-methyltransferase 3B (Q9UBC3) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UBC3
Elsewhere: RCSB PDB 3FLG · PDBe 3FLG · UniProt Q9UBC3

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