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Influence of the incorporation of a cyclohexenyl nucleic acid (cena) residue onto the sequence D(GCGTGCG)/D(CGCACGC)

Analyse Influence of the incorporation of a cyclohexenyl nucleic acid (cena) residue… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3FL6
Type
DNA
Length
28 nucleotides
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-D(*GP*CP*GP*(XTR)P*GP*CP*G)-3'; 5'-D(*CP*GP*CP*AP*CP*GP*C)-3'
Ligands
NCO

Structure

x-ray diffraction · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, C5'-D(*GP*CP*GP*(XTR)P*GP*CP*G)-3'dna7——
B, D5'-D(*CP*GP*CP*AP*CP*GP*C)-3'dna7——

Ligands and binding sites

  • NCO · Cobalt hexammine(iii) · ligand · 7 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

  • C–D · 285 Ų buried · 22 hydrogen bonds · nucleic-nucleic
  • A–B · 285 Ų buried · 24 hydrogen bonds · nucleic-nucleic
  • A–C · 25 Ų buried · 0 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 2 modified (nucleotide modification).

Compared structures

  • 3FL6 · Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the… · the same entry in another collection · chain A against A, TM-score 1.00

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