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Crystal structure of methanocaldococcus jannaschii 8-oxoguanine DNA glycosylase (mjogg)

Analyse Crystal structure of methanocaldococcus jannaschii 8-oxoguanine DNA glycosylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FHF
Type: protein
Length: 214 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N-GLYCOSYLASE/DNA lyase
EC: 3.2.2.-, 4.2.99.18
UniProt: Q58134
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	N-GLYCOSYLASE/DNA lyase (EC 3.2.2.-, 4.2.99.18)	protein	214	71% helix, 0% strand	Q58134

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	274	0.59	0.78	34	empty
2	89	0.54	0.84	14	empty
3	69	0.31	0.74	17	empty

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

3FHF · Crystal structure of Methanocaldococcus jannaschii 8-oxoguanine DNA glycosylase (MjOgg) · the same entry in another collection · chain A against A, TM-score 1.00
Q58134 · AlphaFold monomer V2.0 prediction for 8-oxoguanine DNA GLYCOSYLASE/AP lyase (Q58134) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q58134
Elsewhere: RCSB PDB 3FHF · PDBe 3FHF · UniProt Q58134

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