Research workbench
Crystal structures of mutants reveal a signalling pathway for activation of the kinesin motor ATPase
Analyse Crystal structures of mutants reveal a signalling pathway for activation of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1F9U
- Type
- protein
- Length
- 310 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KAR3
- UniProt
- P17119
- Ligands
- ADP, MG
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KAR3 | protein | 310 | 36% helix, 30% strand | P17119 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.54 | 0.86 | 21 | empty |
| 2 | 120 | 0.45 | 0.78 | 33 | MG, ADP |
| 3 | 69 | 0.30 | 0.74 | 15 | empty |
| 4 | 60 | 0.29 | 0.74 | 16 | empty |
Compared structures
- 1F9U · Crystal structures of mutants reveal a signalling pathway for activation of the kinesin… · the same entry in another collection · chain A against A, TM-score 1.00
- P17119 · AlphaFold monomer V2.0 prediction for kinesin-like protein KAR3 (P17119) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17119
- Elsewhere: RCSB PDB 1F9U · PDBe 1F9U · UniProt P17119
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