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Crystal structure of trypanosoma brucei phosphomannosemutase, TB.10.700.370

Analyse Crystal structure of trypanosoma brucei phosphomannosemutase, TB.10.700.370 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3F9R
Type: protein
Length: 492 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphomannomutase
EC: 5.4.2.8
UniProt: Q38AW2
Ligands: MG, SO4
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Phosphomannomutase (EC 5.4.2.8)	protein	246	41% helix, 22% strand	Q38AW2

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.76	0.96	26	empty
2	352	0.71	0.84	52	SO4
3	372	0.69	0.82	53	SO4
4	59	0.29	0.75	17	empty
5	55	0.28	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 754 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3F9R · Crystal Structure of Trypanosoma Brucei phosphomannosemutase, TB.10.700.370 · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q38AW2
Elsewhere: RCSB PDB 3F9R · PDBe 3F9R · UniProt Q38AW2

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