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Re-refinement of uncomplexed plasmepsin II from plasmodium falciparum.

Analyse Re-refinement of uncomplexed plasmepsin II from plasmodium falciparum. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3F9Q
Type: protein
Length: 325 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasmepsin-2
EC: 3.4.23.39
UniProt: P46925
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasmepsin-2 (EC 3.4.23.39)	protein	325	14% helix, 46% strand	P46925

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	270	0.57	0.77	35	empty
2	163	0.50	0.78	22	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3F9Q · Re-refinement of uncomplexed plasmepsin II from Plasmodium falciparum. · the same entry in another collection · chain A against A, TM-score 1.00
P46925 · AlphaFold monomer V2.0 prediction for plasmepsin-2 (P46925) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46925
Elsewhere: RCSB PDB 3F9Q · PDBe 3F9Q · UniProt P46925

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