Research workbench
Kcsa potassium channel in the partially open state with 17 a opening at T112
Analyse Kcsa potassium channel in the partially open state with 17 a opening at T112 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3F7Y
- Type
- protein
- Length
- 519 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody Fab fragment heavy chain; Antibody Fab fragment light chain; Voltage-gated…
- UniProt
- P0A334
- Ligands
- K
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody Fab fragment heavy chain | protein | 219 | 5% helix, 51% strand | — |
| B | Antibody Fab fragment light chain | protein | 212 | 6% helix, 51% strand | — |
| C | Voltage-gated potassium channel | protein | 88 | 69% helix, 0% strand | P0A334 |
Ligands and binding sites
- K · Potassium ion · metal · 4 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.68 | 0.76 | 57 | empty |
| 2 | 59 | 0.58 | 0.90 | 15 | empty |
| 3 | 169 | 0.53 | 0.79 | 35 | empty |
| 4 | 169 | 0.51 | 0.78 | 31 | empty |
| 5 | 53 | 0.47 | 0.86 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1858 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 501 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 397 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3F7Y · KcsA Potassium channel in the partially open state with 17 A opening at T112 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A334
- Elsewhere: RCSB PDB 3F7Y · PDBe 3F7Y · UniProt P0A334
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