Research workbench

Structure of influenza haemagglutinin in complex with an inhibitor of membrane fusion

Analyse Structure of influenza haemagglutinin in complex with an inhibitor of membrane… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3EYJ
Type: protein
Length: 491 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain
UniProt: P26137
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hemagglutinin HA1 chain	protein	319	10% helix, 39% strand	P26137
B	Hemagglutinin HA2 chain	protein	172	58% helix, 13% strand	P26137

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.61	0.79	36	empty
2	82	0.48	0.82	21	empty

Interfaces

1 interface between chains.

A–B · 3034 Å² buried · 43 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3EYJ · Structure of Influenza Haemagglutinin in complex with an inhibitor of membrane fusion · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26137
Elsewhere: RCSB PDB 3EYJ · PDBe 3EYJ · UniProt P26137

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.