Research workbench
Crystal structure of the thioredoxin-fold domain of human phosducin- like protein 2
Analyse Crystal structure of the thioredoxin-fold domain of human phosducin- like… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EVI
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosducin-like protein 2
- UniProt
- Q8N4E4
- Ligands
- NA
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosducin-like protein 2 | protein | 118 | 34% helix, 24% strand | Q8N4E4 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.62 | 0.78 | 32 | PEG |
Interfaces
1 interface between chains.
- A–B · 420 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3EVI · Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N4E4 · AlphaFold monomer V2.0 prediction for phosducin-like protein 2 (Q8N4E4) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N4E4
- Elsewhere: RCSB PDB 3EVI · PDBe 3EVI · UniProt Q8N4E4
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