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Crystal structure of a fungal type III polyketide synthase, oras
Analyse Crystal structure of a fungal type III polyketide synthase, oras in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EUO
- Type
- protein
- Length
- 758 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type III pentaketide synthase
- UniProt
- Q7S6N4
- Pockets
- 7 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Type III pentaketide synthase | protein | 379 | 46% helix, 22% strand | Q7S6N4 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 329 | 0.79 | 0.89 | 66 | empty |
| 2 | 301 | 0.77 | 0.89 | 62 | empty |
| 3 | 66 | 0.46 | 0.83 | 14 | empty |
| 4 | 65 | 0.44 | 0.82 | 15 | empty |
| 5 | 123 | 0.40 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2417 Ų buried · 43 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 3EUO · crystal structure of a fungal type III polyketide synthase, ORAS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7S6N4
- Elsewhere: RCSB PDB 3EUO · PDBe 3EUO · UniProt Q7S6N4
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