Research workbench
Crystal structure of histidinol-phosphate aminotransferase (YP_297314.1) from ralstonia eutropha JMP134 at 2.05 a resolution
Analyse Crystal structure of histidinol-phosphate aminotransferase (YP_297314.1) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EUC
- Type
- protein
- Length
- 722 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidinol-phosphate aminotransferase 2
- EC
- 2.6.1.9
- UniProt
- Q46WL3
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.90
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidinol-phosphate aminotransferase 2 (EC 2.6.1.9) | protein | 365 | 42% helix, 16% strand | Q46WL3 |
| B | Histidinol-phosphate aminotransferase 2 (EC 2.6.1.9) | protein | 357 | 44% helix, 17% strand | Q46WL3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.90 | 0.92 | 123 | SO4, GOL |
| 2 | 118 | 0.56 | 0.83 | 25 | empty |
| 3 | 56 | 0.50 | 0.86 | 21 | empty |
| 4 | 57 | 0.45 | 0.83 | 19 | SO4, GOL |
| 5 | 96 | 0.41 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3356 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 31 modified (engineered).
Compared structures
- 3EUC · Crystal structure of histidinol-phosphate aminotransferase (YP_297314.1) from RALSTONIA… · the same entry in another collection · chain A against A, TM-score 1.00
- Q46WL3 · AlphaFold monomer V2.0 prediction for histidinol-phosphate aminotransferase 2 (Q46WL3) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q46WL3
- Elsewhere: RCSB PDB 3EUC · PDBe 3EUC · UniProt Q46WL3
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